An Alternative to Surgery to Sterilize Male Dogs
- An injectable chemical sterilization drug will be available for use in the U.S. by the end of this year. It is currently FDA-approved only for dogs from 3 to 10 months, but the manufacturer believes it will be approved as safe for all dogs 3 months and older by the time it is released.
- The drug, brand name Zeuterin, contains zinc gluconate neutralized by arginine. It acts as a spermicide and causes irreversible fibrosis of the testicles, which eventually atrophy and shrink in size, but remain visible.
- Upon its initial release, Zeuterin will be made available primarily to shelters and spay-neuter clinics. The drug can only be sold to licensed veterinarians who have been trained in the injection procedure by the manufacturer.
- The drug is highly effective at sterilizing male dogs with a single injection in each testicle. There are some side effects which seem primarily related to the injection technique.
- It’s important to understand no sterilization procedure is completely risk-free, short or long-term. Once Zeuterin is widely available to private veterinary practitioners, we encourage dog owners to discuss with their vet the pros and cons of the procedure vs. traditional spaying or neutering.
By Dr. Becker
An injectable sterilization product for male dogs containing zinc gluconate neutralized with arginine is scheduled for release in the U.S. by the end of this year under the brand name Zeuterin ("zinc neutering"). The product is already in use in Bolivia, Columbia, Mexico and Panama under another name.
The drug is effective for permanent sterilization of male dogs at least three months of age. Zeuterin has been approved by the FDA for use in dogs three to ten months of age and can be obtained only by licensed veterinarians who have received training from the drug’s manufacturer, Ark Sciences, in how to perform the injections. The manufacturer believes the drug will be approved for use in dogs of any age over three months before the U.S. release date.
The drug functions as a spermicide and causes irreversible fibrosis of the testicles, which eventually atrophy and shrink in size, but remain visible. Dogs receiving the injection are tattooed in the groin area as proof they are sterile.
Product Launch Aimed at Shelters and Spay-Neuter Clinics Across the U.S.
Many shelters and spay-neuter facilities don’t have the recovery space for animals after sterilization surgery. For those organizations, Zeuterin should save time, money and space.
The injections are done on an outpatient basis, no anesthesia is involved, and dogs can be released relatively quickly after the procedure. Shelters and spay-neuter programs can then transfer some of the resources formerly committed to neutering male dogs toward spaying females and other outreach programs.
Proponents of Zeuterin believe it is unlikely individual veterinary practitioners will immediately embrace the sterilization drug, simply because they are already equipped and trained to do surgical spays and neuters. In addition, at this time Ark Sciences is training only a limited number of private veterinarians to inject Zeuterin.
Pet owners who want to have their male puppy chemically sterilized can add their names to a waiting list, which will at some point trigger Ark Sciences to send an offer to their vet to get certified to inject Zeuterin. According to Ark Sciences, the waiting list will be worked on a first-come first-served basis when the product becomes available.
It’s impossible to predict when Zeuterin might be widely available as an option for private vet practices and individual pet owners. Whenever that time comes, I think it’s important to understand the potential risks and benefits of this method of sterilizing male dogs.
Technology Approved by FDA in 2003
The formulation of zinc gluconate neutralized by arginine was actually approved by the FDA in 20031. That same year the drug was produced by Pet Healthcare International and distributed in the U.S. by Addison Laboratories under the name Neutersol.
According to Ark Sciences, Addison Labs overestimated the demand for the drug and created too much inventory. Excess inventory expired in two years, Pet Healthcare International went unpaid, and production shut down. Addison Labs and Pet Healthcare ended their relationship in 2005.
Ark Sciences subsequently acquired all rights to the Neutersol technology and has been distributing the product in Mexico and three other countries under the name Esterilsol for the last four years. They have used the drug extensively in Mexico in dogs three months and older to further evaluate its effectiveness as a sterilization agent, as well as to refine and improve the injection technique.
How the Drug Works as a Sterilization Agent
According to the Alliance for Contraception in Cats and Dogs (ACC&D) in their April 2012 Product Profile and Position Paper2 on Zeuterin:
As with any medical intervention, safety and effectiveness depend upon proper administration. The exact mechanism of action is not known. The following is based on a description provided by Ark Sciences. The product should be administered as an intratesticular injection into the center of the testicle via the dorsal cranial portion of testicle, parallel to the longitudinal axis. After injection the compound diffuses in all directions from the center of the testis. In the concentration used, zinc gluconate acts as a spermicide and destroys spermatozoa in all stages of development and maturation. It results in permanent and irreversible fibrosis in the seminiferous tubules, rete testis and epididymis. This produces a reduction in the size and texture of the testicles and permanent sterilization. Testosterone production is reduced by 41-52%, and the endocrine feedback system remains intact. Zinc gluconate is absorbed and metabolized by the body within 72 hours after the injection.
Also, from the Ark Sciences FAQ web page3:
How is testosterone lowered by Zinc Gluconate neutralized with Arginine?
The dosage and concentration is designed to ensure Leydig Cells in the interstitial space of the testes survive the procedure. Stimulated by Luteinizing Hormone (LH) produced in the pituitary gland, the Leydig Cells continue to support testosterone-related metabolic activity and growth. In the absence of spermatogenesis, Sertoli cells stop communicating the need for testosterone to mature sperm cells. The pituitary gland detects this lowered demand and lowers the LH levels. Since LH levels determine how much testosterone is produced by the Leydig cells, overall testosterone levels are reduced by 41-52% for all dogs permanently.
Zeuterin Adverse Reactions
The 2003 FDA drug approval document includes a study of 270 male puppies injected with the chemical sterilant. The puppies were a combination of shelter animals and family pets.
The following reactions were noted:
Reactions Upon Injection
Biting and Licking
Dry Scrotal Skin
Another zinc gluconate sterilization study was done in the Galápagos Islands and published in 2008. It was conducted in a cooperative effort by the University of Florida, the ASPCA, and Animal Balance of San Francisco, and titled "Comparison of intratesticular injection of zinc gluconate versus surgical castration to sterilize male dogs."4 The following observation was made by the researchers:
Although the complication rate was similar for surgical and zinc-gluconate castration, the zinc-gluconate reactions were more severe. Surgical wound complications were treated by superficial wound debridement and resuturing. In contrast, zinc-gluconate reactions required antimicrobial treatment, orchiectomy, and extensive surgical debridement and reconstruction, including scrotal ablation in 2 dogs. These reactions occurred following administration by both experienced and novice individuals. All dogs made a full recovery following treatment of zinc-gluconate reactions and incisional dehiscences.
The authors of this study determined that proper injection technique is critical because injection or leakage into surrounding tissues can result in severe tissue damage. And while scrotal swelling and tenderness are common in the first days after injection, a more serious reaction is the development of scrotal ulcers or draining tracts in the scrotal or preputial area. The self-trauma that follows can be severe.
The researchers also observed that lesions aren’t always restricted to the injection site, which could indicate the solution may spread beyond the target area.
Long-Term Side Effects
According to Ark Sciences, since 1999 when the initial clinical studies were performed, there have been no reports of long-term side effects.
I would just add here that whenever we manipulate nature sufficiently to stop procreation, there WILL be long-term side effects. This is true for spay/neuter, and any other method. We are just beginning to understand the lifelong implications of surgical removal of ovaries and testicles, yet spaying and neutering of cats and dogs has been a common practice for decades.
I’m certainly not against the sterilization of pets. I’m a proponent of assessing the risks and benefits of everything we do as guardians of the animals in our care.
You can read more about Zeuterin on the Ark Sciences FAQ page as well as the other documents linked in the references, below.
Once the product is widely available to private veterinary practitioners, if you’re considering it, I recommend talking with your vet about the pros and cons of the procedure for your own dog.
Related:Technorati Tags: pet surgery,Zeuterin,Dr. Becker,spay-neuter clinics,spay/neuter,spay,neuter,male dogs,zinc gluconate sterilization,Pet Health,drug side affects,dogs,JOMP,Just One More Pet,pet sterilization,manipulate nature,fake dog testicles,sterilization of pets,spay-neuter,injectable sterilization product
August 17, 2012 - Posted by justonemorepet | Adopt Just One More Pet, Animal or Pet Related Stories, Animal Related Education, Dogs, Dogs, If Animlas Could Talk..., Just One More Pet, Man's Best Friend, Pet Friendship and Love, Pet Health, Pets, responsible pet ownership | Dr. Becker, male dogs, manipulating nature, Neuter, neutering, pet surgery, Spay, spay-neuter clinics, spay/neuter, sterilization of pets, veterinary medicine, Zeuterin, zinc gluconate sterilization
4 Comments »
Save a Life…Adopt Just One More…Pet!
Everyday we read or hear another story about pets and other animals being abandoned in record numbers while at the same time we regularly hear about crazy new rules and laws being passed limiting the amount of pets that people may have, even down to one or two… or worse yet, none.
Nobody is promoting hoarding pets or animals, but at a time when there are more pets and animals of all types being abandoned or being taken to shelters already bursting at the seams, there is nothing crazier than legislating away the ability of willing adoptive families to take in just one more pet!!
Our goal is to raise awareness and help find homes for all pets and animals that need one by helping to match them with loving families and positive situations. Our goal is also to help fight the trend of unfavorable legislation and rules in an attempt to stop unnecessary Euthenization!!
“All over the world, major universities are researching the therapeutic value of pets in our society and the number of hospitals, nursing homes, prisons and mental institutions which are employing full-time pet therapists and animals is increasing daily.” ~ Betty White, American Actress, Animal Activist, and Author of Pet Love
So if you have the room in your home and the love in your heart… Adopt Just One More Pet or consider becoming a Foster parent for pets… Also check out: Little Critter: Just One More Pet
Photos By: Marion Algier – The UCLA Shutterbug
There is always room for Just One More Pet. So if you have room in your home and room in your heart… Adopt Just One More! If you live in an area that promotes unreasonable limitations on pets… fight the good fight and help change the rules and legislation…
Save the Life of Just One More…Animal!
Recent and Seasonal Shots
As I have been fighting Cancer… A battle I am gratefully winning, my furkids have not left my side. They have been a large part of my recovery!! Ask Marion
Photos by the UCLA Shutterbug are protected by copyright, Please email at JustOneMorePet@gmail.com or find us on twitter @JustOneMorePet for permission to duplicate for commerical purposes or to purchase photos.
If you can adopt or foster just one more pet, you could be saving a life, while adding joy to your own! Our shelters are over-flowing… Please join the fight to make them all ‘NO-Kill’ facilities.
Help Make a Difference
Protect Your Pet From Tarter and Gum DiseasePlaque Attack Triple Care Dental Spray Amazon.com Widgets
Adopt Just One More Pet All Animals All Pets animal abuse animal advocacy animal advocates animal cruelty animals ASPCA Bears be part of the solution Birds California cancer canines Cats cats and dogs Chihuahuas China Chiweenies Christmas cute dog Doggies dogs dogs and cats Dr. Becker elephants Fido fish for the love of a pet German Shepherd Halloween holidays holidays with pets horses HSUS Humane Society Humane Society of the United States JOMP Just One More Pet JustOneMorePet kittens kitties livestock Love man's best friend man's best friends military dogs monkeys New York Pet Abuse Pet Adoption Pet costumes Pet Food pet fun Pet Health Pet Parents Pets pet safety pets and holidays Pets Are Family Pet Therapy Puppies puppy mills pups rabbits reptiles responsible pet ownership responsible pet parents service dogs Stop Animal Cruelty Texas There Is Always Room For One More Pet we are their voice
- Chicago-area dog flu cases climb to over 1,100, including six deaths April 16, 2015(Joop Snijder Jr. | Shutterstock) April 15, 2015 – Reuters At least 1,137 Chicago-area dogs have come down with a highly contagious strain of canine flu, and six have died, in the largest and longest-lasting dog flu outbreak ever seen in the region, county officials said on Tuesday. Veterinarians began reporting cases of Canine Infectious […]justonemorepet
- Unusual Friends March 21, 2015By Marion Algier – JOMP Big Dog and Calf are virtually same size and new best friendsjustonemorepet
- Hermosa March 21, 2015By Marion Algier – JOMP St. Patrick’s Day Baby… Hermosa. Our niece adopted a Mustang, Eclipse, who was pregnant. Eclipse gave birth to her new baby midday; a wonderful St. Patty’s Day gift. Welcome little filly!justonemorepet
- Nevada Law Would Make ‘Pot for Pets’ Legal March 19, 2015Medical marijuana is dispensed at the Takoma Wellness Center, Oct. 10, 2014, in Takoma Park, DC. Evelyn Hockstein/The Washington Post/Getty Images ABC Health News – Mar 18, 2015, 1:54 PM ET - By LIZ NEPORENT – Cross-Posted at Just One More Pet (JOMP) and True Health Is True Wealth (THITW) A new bill introduced […]justonemorepet
- Hero Dog Saves Owner Clinically Dead for 30-Minutes March 12, 2015Life With Dogs: A woman named Joanna Mellor had her life saved after going into cardiac arrest and being clinically dead for half an hour when her dog barked until her boyfriend woke up and called for an ambulance. The UK woman was sleeping on January 2nd when she suffered a heart attack and stopped […]justonemorepet
- Good Dog: Small Dog, Big Heart February 26, 2015Illustration by John Cuneo by Wells Tower – June/July 2014 – Garden & Gun – Cross-Posted at Just One More Pet The nervous work of owning—and finally loving—a Chihuahua For many years, I thought that owners of small dogs harbored stunted souls. Parents of infant beauty queens. Weird bachelors with pet stairs by their beds. […]justonemorepet
- Dog Mourns The Heart-Breaking Loss Of His Brother January 31, 2015Brutus Cries for Brother Hank By Marion Algier – Just One More Pet The message… animals have feelings too. This shows one dog’s reaction to finding out his twin brother had passed during the night. Brutus, does not want to leave his brother Hanks side even after he’s passed away. Brutus stays close, and […]justonemorepet
- GoDaddy pulls ‘lost puppy’ Super Bowl ad after igniting firestorm on social media January 29, 2015Video: GoDaddy pulls hilarious, humorous or tasteless ‘lost puppy’ Super Bowl ad after igniting firestorm on social media -> You be the judge…justonemorepet
- In Memory of Rosie – Until We Meet Again on Rainbow Bridge January 19, 2015Rosie By Patricia D. Gillenwater Our sweet Rosie passed on to the Rainbow Bridge today after succumbing to the Big C. Rosie came into our lives in a serendipitous moment. She needed us and, after two losses of two wonderful rescue critters for extreme health issues, we needed Rosie. She was with us for nearly […]justonemorepet
- There’s Just One Thing That All Dogs Want To Know January 19, 2015By Harrison’s Natural Dog Training There’s just one thing that all dogs want to know, and they need you to answer it. Between raising the kids and making meals, working a shift, going to soccer games, swimming lessons, making time for your better half, going to the gym walking the dog..well.. the list could go […]justonemorepet
- Chicago-area dog flu cases climb to over 1,100, including six deaths April 16, 2015
Find Pet Friendly Hotels
artiewhitefox on Unusual Friends Nevada Law Would Mak… on Canada marijuana growers use w… Nevada Law Would Mak… on More Dogs (and Cats) Getting H… Nevada Law Would Mak… on Nevada Law Would Make ‘P… Nevada Law Would Mak… on Canada marijuana growers use w…
Error: Twitter did not respond. Please wait a few minutes and refresh this page.
Great Book for Children and Pet Lovers… And a Perfect Holiday GiftOne More Pet Emily loves animals so much that she can’t resist bringing them home. When a local farmer feels under the weather, she is only too eager to “feed the lambs, milk the cows and brush the rams.” The farmer is so grateful for Emily’s help that he gives her a giant egg... Can you guess what happens after that? The rhythmic verse begs to be read aloud, and the lively pictures will delight children as they watch Emily’s collection of pets get bigger and bigger.
~~ 2000+ Dog Books And All Things Dog ~~
Buy Now: A Must Have For Every Pet Owner
- April 2015
- March 2015
- February 2015
- January 2015
- December 2014
- August 2014
- July 2014
- June 2014
- May 2014
- April 2014
- March 2014
- February 2014
- January 2014
- December 2013
- November 2013
- October 2013
- September 2013
- August 2013
- July 2013
- June 2013
- May 2013
- April 2013
- March 2013
- February 2013
- January 2013
- December 2012
- November 2012
- October 2012
- September 2012
- August 2012
- July 2012
- June 2012
- May 2012
- April 2012
- March 2012
- February 2012
- January 2012
- December 2011
- November 2011
- October 2011
- September 2011
- August 2011
- July 2011
- June 2011
- May 2011
- April 2011
- March 2011
- February 2011
- January 2011
- December 2010
- November 2010
- October 2010
- September 2010
- August 2010
- July 2010
- June 2010
- May 2010
- April 2010
- March 2010
- February 2010
- January 2010
- December 2009
- November 2009
- October 2009
- September 2009
- August 2009
- July 2009
- June 2009
- May 2009
- April 2009
- March 2009
- February 2009
- January 2009
- December 2008
- November 2008
- October 2008
- September 2008
- August 2008
If You Were Stranded On An Island…A recent national survey revealed just how much Americans love their companion animals. When respondents were asked whether they’d like to spend life stranded on a deserted island with either their spouse or their pet, over 60% said they would prefer their dog or cat for companionship!